DATE: February 28, 2018
What is the comparative effectiveness of pharmacologic treatments in the prevention of rehospitalization in bipolar disorder?
In this Finnish nationwide cohort study of 18 018 patients, lithium use was associated with the lowest risk of rehospitalization because of mental or somatic disorder. The risk of rehospitalization was about 30% lower during treatment with long-acting injections compared with treatment with their oral counterparts.
In bipolar disorder, lithium should remain the first line of treatment, and long-acting injections might offer a safe, effective option for patients in whom lithium is not suitable.