This lecture discusses the following topics:
- General classification
- Cellular actions of opioid receptors
- Anatomical distribution and physiologic effects of mu, delta and kappa receptors
- Agonists and antagonists
- ORL-1 receptors
Provides an introduction to the classification of opioid receptors, it also discusses the cellular effects of opioid receptor activation (presynaptic inhibition of neurotransmitter release).
Lists the most relevant agonists and antagonists for the different subtypes of opioid receptor, then effects upon activation (opioid physiology) are reviewed.
An overview on the recently discovered ORL1 receptor.
- Katzung, B. Basic and Clinical Pharmacology. 11th ed. McGraw Hill Medical, 2009
- Koneru A, Sreemantula S, Rizwan. Endogenous Opioids: Their Physiological Role and Receptors. Global J. Pharmacol., 3 (3): 149-153, 2009
- McDonald J, Lambert DJ. Opioid Receptors. Continuing Education in Anaesthesia, Critical Care & Pain 2005 5:1
- Trescot A, Sukdeb D. Opioid Pharmacology. Pain Physician 2008; 11:S133-S153