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First pill with a sensor approved by the FDA

12/14/2017

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Peters-Strickland T, Pestreich L, Hatch A, Rohatagi S, Baker RA, Docherty JP, Markovtsova L, Raja P, Weiden PJ, Walling DP. Usability of a novel digital medicine system in adults with schizophrenia treated with sensor-embedded tablets of aripiprazole. Neuropsychiatr Dis Treat. 2016 Oct 11;12:2587-2594. eCollection 2016. PubMed PMID: 27785036; PubMed Central PMCID: PMC5067053.
Masand P, Han C, Pae CU. Will the Proteus sensor enhance adherence to aripiprazole or other antipsychotics? Expert Rev Neurother. 2017 Apr;17(4):319-321. PubMed PMID: 28132567.


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Does turning down blue light in smartphones really work?

12/11/2017

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Heo JY, Kim K, Fava M, Mischoulon D, Papakostas GI, Kim MJ, Kim DJ, Chang KJ, Oh Y, Yu BH, Jeon HJ. Effects of smartphone use with and without blue light at night in healthy adults: A randomized, double-blind, cross-over, placebo-controlled comparison. J Psychiatr Res. 2017 Apr;87:61-70. PubMed PMID: 28017916.

Background
Smartphones deliver light to users through Light Emitting Diode (LED) displays.
In this light, blue light has the most potent effect on sleep and mood. So, it has been suggested that if blue light could be suppressed, the harmful effect of light from smartphone screens could be significantly reduced.
This study, funded by Samsung Display in South Korea, looked at this question.
This is the first controlled study of the effects of exposure of blue light from smartphone LED displays at night on humans.

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Can ADHD start in adolescence or adulthood?

12/6/2017

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Sibley MH, Rohde LA, Swanson JM, Hechtman LT, Molina BSG, Mitchell JT, Arnold LE, Caye A, Kennedy TM, Roy A, Stehli A; Multimodal Treatment Study of Children with ADHD (MTA) Cooperative Group. Late-Onset ADHD Reconsidered With Comprehensive Repeated Assessments Between Ages 10 and 25. Am J Psychiatry. 2017 Oct 20:appiajp201717030298. [Epub ahead of print] PubMed PMID: 29050505.

Background
It is fairly common that we see an adolescent or a young adult who presents to us seeking treatment for symptoms of attention deficit/hyperactivity disorder (ADHD) but who does not have a history of ADHD in childhood.
Recently, some studies that enrolled children at an early age and then followed them for many years (called “birth cohort” studies) have suggested that a “late-onset” form of ADHD also exists.
But, the authors of the paper we are discussing here argue that the birth-cohort studies previously done have many limitations. Specifically, they identified ADHD only by screening questionnaires, did not consider alternative causes of the ADHD-like symptoms, and did not obtain complete psychiatric histories.
In this study, the authors have tried to address the limitations of previous studies by looking at more detailed psychiatric assessments administered over time.


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