BEYOND THE BRAIN BLOG
  • Blog
  • Author
  • Resources
    • Bookstore
    • Downloads
    • Provider Tools
    • Patient Resources
    • Speakers & Talks
    • Ketogenic Diet
  • For Patients
  • Contact

Mistimed Sleep Disrupts Circadian Regulation of Gene Expression

1/25/2014

0 Comments

 
SOURCE: MPR - HealthDay News
Picture
Delaying sleep by just a few hours for several days reduces circadian gene expression in the blood six-fold without affecting centrally-driven melatonin circadian rhythms, according to a study published online Jan. 20 in the Proceedings of the National Academy of Sciences.

Simon N. Archer, PhD, from the University of Surrey in Guildford, UK, and colleagues analyzed changes in gene expression in the blood of 22 healthy volunteers who were placed on a mistimed sleep cycle, where sleep was delayed by four hours for three consecutive days.

The researchers found that mistimed sleep led to a reduction in circadian transcripts in the blood, from 6.4% to 1%, without affecting the centrally-driven circadian rhythm of melatonin. The genes affected included those associated with chromatin modification, transcription, translation, temperature-regulated transcription, and core clock genes.

"The data show that mistimed sleep affects molecular processes at the core of circadian rhythm generation and imply that appropriate timing of sleep contributes significantly to the overall temporal organization of the human transcriptome," Archer and colleagues conclude.

>> Get the Full Text HERE
0 Comments

Your comment will be posted after it is approved.


Leave a Reply.

    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture


    USEFUL LINKS

    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture
    Picture

    Archives

    December 2018
    July 2018
    June 2018
    May 2018
    April 2018
    March 2018
    February 2018
    January 2018
    December 2017
    August 2017
    January 2017
    November 2016
    September 2016
    August 2016
    July 2016
    May 2016
    March 2016
    February 2016
    December 2015
    November 2015
    October 2015
    September 2015
    July 2015
    June 2015
    May 2015
    April 2015
    March 2015
    January 2015
    December 2014
    November 2014
    October 2014
    September 2014
    August 2014
    July 2014
    June 2014
    May 2014
    April 2014
    March 2014
    February 2014
    January 2014
    December 2013
    November 2013


    following

    Picture
Creative Commons License
Copyright 2013
Beyond the Brain Blog
Beyond the Brain is a not-for-profit website. We appreciate your support to continue providing more content and tools.    Donate today!
BLOG  |  AUTHOR |  RESOURCES |  FOR PATIENTS |  CONTACT  |  SUPPORT BTB